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NUMB-DNM2 Fusion FISH Probe

The NUMB-DNM2 Fusion FISH Probe is used to confirm a fusion of the NUMB and DNM2 genes. The fusion of the NUMB and DNM2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NUMB-DNM2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NUMB-DNM2-20-RERE 20 (40 μL) 200 μL
NUMB-DNM2-20-REOR 20 (40 μL) 200 μL
NUMB-DNM2-20-REGO 20 (40 μL) 200 μL
NUMB-DNM2-20-REGR 20 (40 μL) 200 μL
NUMB-DNM2-20-REAQ 20 (40 μL) 200 μL
NUMB-DNM2-20-ORRE 20 (40 μL) 200 μL
NUMB-DNM2-20-OROR 20 (40 μL) 200 μL
NUMB-DNM2-20-ORGO 20 (40 μL) 200 μL
NUMB-DNM2-20-ORAQ 20 (40 μL) 200 μL
NUMB-DNM2-20-GORE 20 (40 μL) 200 μL
NUMB-DNM2-20-GOOR 20 (40 μL) 200 μL
NUMB-DNM2-20-GOGO 20 (40 μL) 200 μL
NUMB-DNM2-20-GOGR 20 (40 μL) 200 μL
NUMB-DNM2-20-GOAQ 20 (40 μL) 200 μL
NUMB-DNM2-20-GRRE 20 (40 μL) 200 μL
NUMB-DNM2-20-GROR 20 (40 μL) 200 μL
NUMB-DNM2-20-GRGO 20 (40 μL) 200 μL
NUMB-DNM2-20-GRGR 20 (40 μL) 200 μL
NUMB-DNM2-20-GRAQ 20 (40 μL) 200 μL
NUMB-DNM2-20-AQRE 20 (40 μL) 200 μL
NUMB-DNM2-20-AQOR 20 (40 μL) 200 μL
NUMB-DNM2-20-AQGO 20 (40 μL) 200 μL
NUMB-DNM2-20-AQGR 20 (40 μL) 200 μL
NUMB-DNM2-20-AQAQ 20 (40 μL) 200 μL

DNM2 Gene Summary

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Gene Name: Dynamin 2

Chromosome: CHR19: 10828728 -10942586

Locus: 19p13.2

NUMB Gene Summary

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Gene Name: NUMB, Endocytic Adaptor Protein

Chromosome: CHR14: 73741917 -73925286

Locus: 14q24.2-q24.3

Gene Diseases

The NUMB DNM2 Fusion has been associated with the following diseases:

Disease Name
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.