NUMA1-YAP1 Fusion FISH Probe
The NUMA1-YAP1 Fusion FISH Probe is used to confirm a fusion of the NUMA1 and YAP1 genes. The fusion of the NUMA1 and YAP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUMA1-YAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-RERE | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-REOR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-REGO | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-REGR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-OROR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GORE | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GROR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| NUMA1-YAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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NUMA1 Gene Summary
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Nuclear Mitotic Apparatus Protein 1
Chromosome: CHR11: 71713910 -71791573
Locus: 11q13.4
YAP1 Gene Summary
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Gene Name: Yes Associated Protein 1
Chromosome: CHR11: 101981191 -102104154
Locus: 11q22.1
Gene Diseases
The NUMA1 YAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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