NUMA1-PTH Fusion FISH Probe
The NUMA1-PTH Fusion FISH Probe is used to confirm a fusion of the NUMA1 and PTH genes. The fusion of the NUMA1 and PTH genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NUMA1-PTH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NUMA1-PTH-20-AQAQ | 20 (40 μL) | 200 μL |
|
NUMA1 Gene Summary
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Nuclear Mitotic Apparatus Protein 1
Chromosome: CHR11: 71713910 -71791573
Locus: 11q13.4
PTH Gene Summary
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Parathyroid Hormone
Chromosome: CHR11: 13513600 -13517567
Locus: 11p15.3
Gene Diseases
The NUMA1 PTH Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|