NUMA1-EIF2AK2 Fusion FISH Probe
The NUMA1-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the NUMA1 and EIF2AK2 genes. The fusion of the NUMA1 and EIF2AK2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUMA1-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| NUMA1-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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NUMA1 Gene Summary
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Nuclear Mitotic Apparatus Protein 1
Chromosome: CHR11: 71713910 -71791573
Locus: 11q13.4
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The NUMA1 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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