NUMA1-CLPB Fusion FISH Probe
The NUMA1-CLPB Fusion FISH Probe is used to confirm a fusion of the NUMA1 and CLPB genes. The fusion of the NUMA1 and CLPB genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUMA1-CLPB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-RERE | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-REOR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-REGO | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-REGR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-REAQ | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-ORRE | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-OROR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-ORGO | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GORE | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GOOR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GOGO | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GOGR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GRRE | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GROR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GRGO | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GRGR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-AQRE | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-AQOR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-AQGO | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-AQGR | 20 (40 μL) | 200 μL |
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| NUMA1-CLPB-20-AQAQ | 20 (40 μL) | 200 μL |
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NUMA1 Gene Summary
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Nuclear Mitotic Apparatus Protein 1
Chromosome: CHR11: 71713910 -71791573
Locus: 11q13.4
CLPB Gene Summary
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: ClpB Homolog, Mitochondrial AAA ATPase Chaperonin
Chromosome: CHR11: 72003469 -72145568
Locus: 11q13.4
Gene Diseases
The NUMA1 CLPB Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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