NUF2-PHEX Fusion FISH Probe
The NUF2-PHEX Fusion FISH Probe is used to confirm a fusion of the NUF2 and PHEX genes. The fusion of the NUF2 and PHEX genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUF2-PHEX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-RERE | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-REOR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-REGO | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-REGR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-REAQ | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-ORRE | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-OROR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-ORGO | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GORE | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GOOR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GOGO | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GOGR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GRRE | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GROR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GRGO | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GRGR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-AQRE | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-AQOR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-AQGO | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-AQGR | 20 (40 μL) | 200 μL |
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| NUF2-PHEX-20-AQAQ | 20 (40 μL) | 200 μL |
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PHEX Gene Summary
The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Phosphate Regulating Endopeptidase Homolog X-linked
Chromosome: CHRX: 22050920 -22266478
Locus: Xp22.11
NUF2 Gene Summary
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: NUF2, NDC80 Kinetochore Complex Component
Chromosome: CHR1: 163291722 -163325553
Locus: 1q23.3
Gene Diseases
The NUF2 PHEX Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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