NUDT3-CDH12 Fusion FISH Probe
The NUDT3-CDH12 Fusion FISH Probe is used to confirm a fusion of the NUDT3 and CDH12 genes. The fusion of the NUDT3 and CDH12 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUDT3-CDH12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-RERE | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-REOR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-REGO | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-REGR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-REAQ | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-ORRE | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-OROR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-ORGO | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GORE | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GOOR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GOGO | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GOGR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GRRE | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GROR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GRGO | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GRGR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-AQRE | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-AQOR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-AQGO | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-AQGR | 20 (40 μL) | 200 μL |
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| NUDT3-CDH12-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH12 Gene Summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 12
Chromosome: CHR5: 21750972 -22853731
Locus: 5p14.3
NUDT3 Gene Summary
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
Gene Name: Nudix Hydrolase 3
Chromosome: CHR6: 34254972 -34360457
Locus: 6p21.31
Gene Diseases
The NUDT3 CDH12 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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