NUDT21-BBS2 Fusion FISH Probe
The NUDT21-BBS2 Fusion FISH Probe is used to confirm a fusion of the NUDT21 and BBS2 genes. The fusion of the NUDT21 and BBS2 genes has been associated with Uterine Corpus Endometrial Carcinoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUDT21-BBS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-RERE | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-REOR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-REGO | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-REGR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-REAQ | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-ORRE | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-OROR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-ORGO | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GORE | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GOOR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GOGO | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GOGR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GRRE | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GROR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GRGO | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GRGR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-AQRE | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-AQOR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-AQGO | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-AQGR | 20 (40 μL) | 200 μL |
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| NUDT21-BBS2-20-AQAQ | 20 (40 μL) | 200 μL |
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BBS2 Gene Summary
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with seven other BBS proteins.[provided by RefSeq, Oct 2014]
Gene Name: Bardet-Biedl Syndrome 2
Chromosome: CHR16: 56518258 -56554008
Locus: 16q13
NUDT21 Gene Summary
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]
Gene Name: Nudix Hydrolase 21
Chromosome: CHR16: 56463047 -56485261
Locus: 16q13
Gene Diseases
The NUDT21 BBS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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