NUBPL-DOCK2 Fusion FISH Probe
The NUBPL-DOCK2 Fusion FISH Probe is used to confirm a fusion of the NUBPL and DOCK2 genes. The fusion of the NUBPL and DOCK2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUBPL-DOCK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-RERE | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-REOR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-REGO | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-REGR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-REAQ | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-ORRE | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-OROR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-ORGO | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GORE | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GOOR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GOGO | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GOGR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GRRE | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GROR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GRGO | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GRGR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-AQRE | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-AQOR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-AQGO | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-AQGR | 20 (40 μL) | 200 μL |
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| NUBPL-DOCK2-20-AQAQ | 20 (40 μL) | 200 μL |
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DOCK2 Gene Summary
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
Gene Name: Dedicator Of Cytokinesis 2
Chromosome: CHR5: 169064250 -169510386
Locus: 5q35.1
NUBPL Gene Summary
This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Mutations in this gene cause mitochondrial complex I deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Nucleotide Binding Protein Like
Chromosome: CHR14: 32030590 -32330429
Locus: 14q12
Gene Diseases
The NUBPL DOCK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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