NUB1-ABCB8 Fusion FISH Probe
The NUB1-ABCB8 Fusion FISH Probe is used to confirm a fusion of the NUB1 and ABCB8 genes. The fusion of the NUB1 and ABCB8 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUB1-ABCB8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-RERE | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-REOR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-REGO | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-REGR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-REAQ | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-ORRE | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-OROR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-ORGO | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GORE | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GOOR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GOGO | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GOGR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GRRE | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GROR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GRGO | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GRGR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-AQRE | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-AQOR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-AQGO | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-AQGR | 20 (40 μL) | 200 μL |
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| NUB1-ABCB8-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCB8 Gene Summary
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: ATP Binding Cassette Subfamily B Member 8
Chromosome: CHR7: 150725509 -150744869
Locus: 7q36.1
NUB1 Gene Summary
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Negative Regulator Of Ubiquitin Like Proteins 1
Chromosome: CHR7: 151038846 -151075548
Locus: 7q36.1
Gene Diseases
The NUB1 ABCB8 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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