NTHL1-KLRC3 Fusion FISH Probe
The NTHL1-KLRC3 Fusion FISH Probe is used to confirm a fusion of the NTHL1 and KLRC3 genes. The fusion of the NTHL1 and KLRC3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NTHL1-KLRC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-RERE | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-REOR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-REGO | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-REGR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-REAQ | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-ORRE | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-OROR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-ORGO | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GORE | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GOOR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GOGO | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GOGR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GRRE | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GROR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GRGO | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GRGR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-AQRE | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-AQOR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-AQGO | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-AQGR | 20 (40 μL) | 200 μL |
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| NTHL1-KLRC3-20-AQAQ | 20 (40 μL) | 200 μL |
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KLRC3 Gene Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Killer Cell Lectin Like Receptor C3
Chromosome: CHR12: 10564913 -10573194
Locus: 12p13.2
NTHL1 Gene Summary
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
Gene Name: Nth Like DNA Glycosylase 1
Chromosome: CHR16: 2089815 -2097867
Locus: 16p13.3
Gene Diseases
The NTHL1 KLRC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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