NSMCE2-TAF2 Fusion FISH Probe
The NSMCE2-TAF2 Fusion FISH Probe is used to confirm a fusion of the NSMCE2 and TAF2 genes. The fusion of the NSMCE2 and TAF2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NSMCE2-TAF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NSMCE2-TAF2-20-AQAQ | 20 (40 μL) | 200 μL |
|
TAF2 Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
Gene Name: TATA-box Binding Protein Associated Factor 2
Chromosome: CHR8: 120743013 -120845074
Locus: 8q24.12
NSMCE2 Gene Summary
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Gene Name: NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase
Chromosome: CHR8: 126104082 -126379367
Locus: 8q24.13
Gene Diseases
The NSMCE2 TAF2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|