NSMCE2-PACRG Fusion FISH Probe
The NSMCE2-PACRG Fusion FISH Probe is used to confirm a fusion of the NSMCE2 and PACRG genes. The fusion of the NSMCE2 and PACRG genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NSMCE2-PACRG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-RERE | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-REOR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-REGO | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-REGR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-REAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-ORRE | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-OROR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-ORGO | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-ORAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GORE | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GOOR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GOGO | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GOGR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GOAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GRRE | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GROR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GRGO | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GRGR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-GRAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-AQRE | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-AQOR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-AQGO | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-AQGR | 20 (40 μL) | 200 μL |
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| NSMCE2-PACRG-20-AQAQ | 20 (40 μL) | 200 μL |
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PACRG Gene Summary
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Parkin Coregulated
Chromosome: CHR6: 163148163 -163736524
Locus: 6q26
NSMCE2 Gene Summary
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Gene Name: NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase
Chromosome: CHR8: 126104082 -126379367
Locus: 8q24.13
Gene Diseases
The NSMCE2 PACRG Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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