NSMCE2-DCLRE1C Fusion FISH Probe
The NSMCE2-DCLRE1C Fusion FISH Probe is used to confirm a fusion of the NSMCE2 and DCLRE1C genes. The fusion of the NSMCE2 and DCLRE1C genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NSMCE2-DCLRE1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-RERE | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-REOR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-REGO | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-REGR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-REAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-ORRE | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-OROR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-ORGO | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-ORAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GORE | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GOOR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GOGO | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GOGR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GOAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GRRE | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GROR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GRGO | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GRGR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-GRAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-AQRE | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-AQOR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-AQGO | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-AQGR | 20 (40 μL) | 200 μL |
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| NSMCE2-DCLRE1C-20-AQAQ | 20 (40 μL) | 200 μL |
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DCLRE1C Gene Summary
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: DNA Cross-link Repair 1C
Chromosome: CHR10: 14948870 -14996094
Locus: 10p13
NSMCE2 Gene Summary
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Gene Name: NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase
Chromosome: CHR8: 126104082 -126379367
Locus: 8q24.13
Gene Diseases
The NSMCE2 DCLRE1C Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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