NSD1-UNC5A Fusion FISH Probe
The NSD1-UNC5A Fusion FISH Probe is used to confirm a fusion of the NSD1 and UNC5A genes. The fusion of the NSD1 and UNC5A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NSD1-UNC5A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-RERE | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-REOR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-REGO | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-REGR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-REAQ | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-ORRE | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-OROR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-ORGO | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-ORAQ | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GORE | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GOOR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GOGO | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GOGR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GOAQ | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GRRE | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GROR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GRGO | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GRGR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-GRAQ | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-AQRE | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-AQOR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-AQGO | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-AQGR | 20 (40 μL) | 200 μL |
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| NSD1-UNC5A-20-AQAQ | 20 (40 μL) | 200 μL |
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NSD1 Gene Summary
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Binding SET Domain Protein 1
Chromosome: CHR5: 176560079 -176727214
Locus: 5q35.3
UNC5A Gene Summary
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Gene Name: Unc-5 Netrin Receptor A
Chromosome: CHR5: 176237559 -176307899
Locus: 5q35.2
Gene Diseases
The NSD1 UNC5A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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