NSD1-EFNA5 Fusion FISH Probe
The NSD1-EFNA5 Fusion FISH Probe is used to confirm a fusion of the NSD1 and EFNA5 genes. The fusion of the NSD1 and EFNA5 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NSD1-EFNA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-RERE | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-REOR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-REGO | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-REGR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-REAQ | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-ORRE | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-OROR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-ORGO | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GORE | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GOOR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GOGO | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GOGR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GRRE | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GROR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GRGO | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GRGR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-AQRE | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-AQOR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-AQGO | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-AQGR | 20 (40 μL) | 200 μL |
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| NSD1-EFNA5-20-AQAQ | 20 (40 μL) | 200 μL |
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EFNA5 Gene Summary
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Gene Name: Ephrin A5
Chromosome: CHR5: 106712589 -107006596
Locus: 5q21.3
NSD1 Gene Summary
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Binding SET Domain Protein 1
Chromosome: CHR5: 176560079 -176727214
Locus: 5q35.3
Gene Diseases
The NSD1 EFNA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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