NSD1-C11ORF58 Fusion FISH Probe
The NSD1-C11ORF58 Fusion FISH Probe is used to confirm a fusion of the NSD1 and C11ORF58 genes. The fusion of the NSD1 and C11ORF58 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NSD1-C11ORF58-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-RERE | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-REOR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-REGO | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-REGR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-REAQ | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-ORRE | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-OROR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-ORGO | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-ORAQ | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GORE | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GOOR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GOGO | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GOGR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GOAQ | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GRRE | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GROR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GRGO | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GRGR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-GRAQ | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-AQRE | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-AQOR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-AQGO | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-AQGR | 20 (40 μL) | 200 μL |
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| NSD1-C11ORF58-20-AQAQ | 20 (40 μL) | 200 μL |
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C11orf58 Gene Summary
The Chromosome 11 Open Reading Frame 58 (C11orf58) gene is located on chr11 :16760147-16779901 at 11p15.2.
Gene Name: Chromosome 11 Open Reading Frame 58
Chromosome: CHR11: 16760147 -16779901
Locus: 11p15.2
NSD1 Gene Summary
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Binding SET Domain Protein 1
Chromosome: CHR5: 176560079 -176727214
Locus: 5q35.3
Gene Diseases
The NSD1 C11ORF58 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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