NSD1-ARHGAP26 Fusion FISH Probe
The NSD1-ARHGAP26 Fusion FISH Probe is used to confirm a fusion of the NSD1 and ARHGAP26 genes. The fusion of the NSD1 and ARHGAP26 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NSD1-ARHGAP26-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-RERE | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-REOR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-REGO | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-REGR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-REAQ | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-ORRE | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-OROR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-ORGO | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-ORAQ | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GORE | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GOOR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GOGO | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GOGR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GOAQ | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GRRE | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GROR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GRGO | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GRGR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-GRAQ | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-AQRE | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-AQOR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-AQGO | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-AQGR | 20 (40 μL) | 200 μL |
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| NSD1-ARHGAP26-20-AQAQ | 20 (40 μL) | 200 μL |
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ARHGAP26 Gene Summary
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Gene Name: Rho GTPase Activating Protein 26
Chromosome: CHR5: 142150291 -142608572
Locus: 5q31.3
NSD1 Gene Summary
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Binding SET Domain Protein 1
Chromosome: CHR5: 176560079 -176727214
Locus: 5q35.3
Gene Diseases
The NSD1 ARHGAP26 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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