NRXN3-TSHR Fusion FISH Probe
The NRXN3-TSHR Fusion FISH Probe is used to confirm a fusion of the NRXN3 and TSHR genes. The fusion of the NRXN3 and TSHR genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRXN3-TSHR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-RERE | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-REOR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-REGO | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-REGR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-REAQ | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-ORRE | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-OROR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-ORGO | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GORE | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GOOR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GOGO | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GOGR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GRRE | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GROR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GRGO | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GRGR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-AQRE | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-AQOR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-AQGO | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-AQGR | 20 (40 μL) | 200 μL |
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| NRXN3-TSHR-20-AQAQ | 20 (40 μL) | 200 μL |
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TSHR Gene Summary
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Name: Thyroid Stimulating Hormone Receptor
Chromosome: CHR14: 81421868 -81612646
Locus: 14q31.1
NRXN3 Gene Summary
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Gene Name: Neurexin 3
Chromosome: CHR14: 78870092 -80330760
Locus: 14q24.3-q31.1
Gene Diseases
The NRXN3 TSHR Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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