NRXN2-NSD1 Fusion FISH Probe
The NRXN2-NSD1 Fusion FISH Probe is used to confirm a fusion of the NRXN2 and NSD1 genes. The fusion of the NRXN2 and NSD1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NRXN2-NSD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NRXN2-NSD1-20-AQAQ | 20 (40 μL) | 200 μL |
|
NRXN2 Gene Summary
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Gene Name: Neurexin 2
Chromosome: CHR11: 64373645 -64490660
Locus: 11q13.1
NSD1 Gene Summary
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Binding SET Domain Protein 1
Chromosome: CHR5: 176560079 -176727214
Locus: 5q35.3
Gene Diseases
The NRXN2 NSD1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|