NRP2-KLF7 Fusion FISH Probe
The NRP2-KLF7 Fusion FISH Probe is used to confirm a fusion of the NRP2 and KLF7 genes. The fusion of the NRP2 and KLF7 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRP2-KLF7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-RERE | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-REOR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-REGO | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-REGR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-REAQ | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-ORRE | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-OROR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-ORGO | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GORE | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GOOR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GOGO | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GOGR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GRRE | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GROR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GRGO | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GRGR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-AQRE | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-AQOR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-AQGO | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-AQGR | 20 (40 μL) | 200 μL |
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| NRP2-KLF7-20-AQAQ | 20 (40 μL) | 200 μL |
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KLF7 Gene Summary
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Name: Kruppel Like Factor 7
Chromosome: CHR2: 207945528 -208030614
Locus: 2q33.3
NRP2 Gene Summary
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Neuropilin 2
Chromosome: CHR2: 206547223 -206662857
Locus: 2q33.3
Gene Diseases
The NRP2 KLF7 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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