NRP1-PTEN Fusion FISH Probe
The NRP1-PTEN Fusion FISH Probe is used to confirm a fusion of the NRP1 and PTEN genes. The fusion of the NRP1 and PTEN genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRP1-PTEN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-RERE | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-REOR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-REGO | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-REGR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-REAQ | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-ORRE | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-OROR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-ORGO | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GORE | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GOOR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GOGO | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GOGR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GRRE | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GROR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GRGO | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GRGR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-AQRE | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-AQOR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-AQGO | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-AQGR | 20 (40 μL) | 200 μL |
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| NRP1-PTEN-20-AQAQ | 20 (40 μL) | 200 μL |
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PTEN Gene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Name: Phosphatase And Tensin Homolog
Chromosome: CHR10: 89623194 -89728532
Locus: 10q23.31
NRP1 Gene Summary
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Neuropilin 1
Chromosome: CHR10: 33466418 -33623833
Locus: 10p11.22
Gene Diseases
The NRP1 PTEN Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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