NRG1-PMEPA1 Fusion FISH Probe
The NRG1-PMEPA1 Fusion FISH Probe is used to confirm a fusion of the NRG1 and PMEPA1 genes. The fusion of the NRG1 and PMEPA1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRG1-PMEPA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-RERE | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-REOR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-REGO | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-REGR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-REAQ | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-ORRE | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-OROR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-ORGO | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GORE | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GOOR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GOGO | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GOGR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GRRE | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GROR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GRGO | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GRGR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-AQRE | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-AQOR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-AQGO | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-AQGR | 20 (40 μL) | 200 μL |
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| NRG1-PMEPA1-20-AQAQ | 20 (40 μL) | 200 μL |
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NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
PMEPA1 Gene Summary
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Prostate Transmembrane Protein, Androgen Induced 1
Chromosome: CHR20: 56223451 -56286541
Locus: 20q13.31
Gene Diseases
The NRG1 PMEPA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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