NRG1-KRT78 Fusion FISH Probe
The NRG1-KRT78 Fusion FISH Probe is used to confirm a fusion of the NRG1 and KRT78 genes. The fusion of the NRG1 and KRT78 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRG1-KRT78-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-RERE | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-REOR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-REGO | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-REGR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-REAQ | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-ORRE | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-OROR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-ORGO | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GORE | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GOOR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GOGO | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GOGR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GRRE | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GROR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GRGO | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GRGR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-AQRE | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-AQOR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-AQGO | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-AQGR | 20 (40 μL) | 200 μL |
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| NRG1-KRT78-20-AQAQ | 20 (40 μL) | 200 μL |
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NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
KRT78 Gene Summary
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 78
Chromosome: CHR12: 53232745 -53242778
Locus: 12q13.13
Gene Diseases
The NRG1 KRT78 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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