NRF1-MLXIPL Fusion FISH Probe
The NRF1-MLXIPL Fusion FISH Probe is used to confirm a fusion of the NRF1 and MLXIPL genes. The fusion of the NRF1 and MLXIPL genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRF1-MLXIPL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-RERE | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-REOR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-REGO | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-REGR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-REAQ | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-ORRE | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-OROR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-ORGO | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GORE | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GOOR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GOGO | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GOGR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GRRE | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GROR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GRGO | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GRGR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-AQRE | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-AQOR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-AQGO | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-AQGR | 20 (40 μL) | 200 μL |
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| NRF1-MLXIPL-20-AQAQ | 20 (40 μL) | 200 μL |
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NRF1 Gene Summary
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Gene Name: Nuclear Respiratory Factor 1
Chromosome: CHR7: 129251554 -129396922
Locus: 7q32.2
MLXIPL Gene Summary
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: MLX Interacting Protein Like
Chromosome: CHR7: 73007523 -73038870
Locus: 7q11.23
Gene Diseases
The NRF1 MLXIPL Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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