NRAS-CLDN14 Fusion FISH Probe
The NRAS-CLDN14 Fusion FISH Probe is used to confirm a fusion of the NRAS and CLDN14 genes. The fusion of the NRAS and CLDN14 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRAS-CLDN14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-RERE | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-REOR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-REGO | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-REGR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-REAQ | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-ORRE | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-OROR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-ORGO | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GORE | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GOOR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GOGO | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GOGR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GRRE | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GROR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GRGO | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GRGR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-AQRE | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-AQOR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-AQGO | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-AQGR | 20 (40 μL) | 200 μL |
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| NRAS-CLDN14-20-AQAQ | 20 (40 μL) | 200 μL |
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NRAS Gene Summary
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Gene Name: NRAS Proto-oncogene, GTPase
Chromosome: CHR1: 115247084 -115259515
Locus: 1p13.2
CLDN14 Gene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Name: Claudin 14
Chromosome: CHR21: 37832919 -37948867
Locus: 21q22.13
Gene Diseases
The NRAS CLDN14 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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