NR3C1-HMHB1 Fusion FISH Probe
The NR3C1-HMHB1 Fusion FISH Probe is used to confirm a fusion of the NR3C1 and HMHB1 genes. The fusion of the NR3C1 and HMHB1 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NR3C1-HMHB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-RERE | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-REOR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-REGO | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-REGR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-REAQ | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-ORRE | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-OROR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-ORGO | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GORE | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GOOR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GOGO | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GOGR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GRRE | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GROR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GRGO | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GRGR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-AQRE | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-AQOR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-AQGO | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-AQGR | 20 (40 μL) | 200 μL |
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| NR3C1-HMHB1-20-AQAQ | 20 (40 μL) | 200 μL |
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NR3C1 Gene Summary
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Gene Name: Nuclear Receptor Subfamily 3 Group C Member 1
Chromosome: CHR5: 142657495 -142815077
Locus: 5q31.3
HMHB1 Gene Summary
This gene encodes one of the minor histocompatibility antigens, which play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human histocompatibility leukocyte antigen (HLA)-identical allogeneic bone marrow transplantation (BMT). This gene is only expressed in B cell acute lymphoblastic leukemia cells and Epstein-Barr virus-transformed B cells. The translation of this mRNA initiates at a non-AUG (CUG) codon. [provided by RefSeq, Jul 2008]
Gene Name: Histocompatibility Minor HB-1
Chromosome: CHR5: 143191725 -143200284
Locus: 5q31.3
Gene Diseases
The NR3C1 HMHB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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