NR2C2-PARL Fusion FISH Probe
The NR2C2-PARL Fusion FISH Probe is used to confirm a fusion of the NR2C2 and PARL genes. The fusion of the NR2C2 and PARL genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NR2C2-PARL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NR2C2-PARL-20-AQAQ | 20 (40 μL) | 200 μL |
|
NR2C2 Gene Summary
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Nuclear Receptor Subfamily 2 Group C Member 2
Chromosome: CHR3: 14989235 -15090780
Locus: 3p25.1
PARL Gene Summary
This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
Gene Name: Presenilin Associated Rhomboid Like
Chromosome: CHR3: 183547172 -183602693
Locus: 3q27.1
Gene Diseases
The NR2C2 PARL Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|