NR2C1-BCL7A Fusion FISH Probe
The NR2C1-BCL7A Fusion FISH Probe is used to confirm a fusion of the NR2C1 and BCL7A genes. The fusion of the NR2C1 and BCL7A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NR2C1-BCL7A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-RERE | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-REOR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-REGO | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-REGR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-REAQ | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-ORRE | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-OROR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-ORGO | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-ORAQ | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GORE | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GOOR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GOGO | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GOGR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GOAQ | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GRRE | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GROR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GRGO | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GRGR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-GRAQ | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-AQRE | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-AQOR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-AQGO | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-AQGR | 20 (40 μL) | 200 μL |
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| NR2C1-BCL7A-20-AQAQ | 20 (40 μL) | 200 μL |
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BCL7A Gene Summary
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCL Tumor Suppressor 7A
Chromosome: CHR12: 122459860 -122499950
Locus: 12q24.31
NR2C1 Gene Summary
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Subfamily 2 Group C Member 1
Chromosome: CHR12: 95414057 -95467404
Locus: 12q22
Gene Diseases
The NR2C1 BCL7A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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