NPLOC4-P4HB Fusion FISH Probe
The NPLOC4-P4HB Fusion FISH Probe is used to confirm a fusion of the NPLOC4 and P4HB genes. The fusion of the NPLOC4 and P4HB genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NPLOC4-P4HB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-RERE | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-REOR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-REGO | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-REGR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-REAQ | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-ORRE | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-OROR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-ORGO | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-ORAQ | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GORE | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GOOR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GOGO | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GOGR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GOAQ | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GRRE | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GROR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GRGO | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GRGR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-GRAQ | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-AQRE | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-AQOR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-AQGO | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-AQGR | 20 (40 μL) | 200 μL |
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| NPLOC4-P4HB-20-AQAQ | 20 (40 μL) | 200 μL |
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P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
NPLOC4 Gene Summary
The NPL4 Homolog, Ubiquitin Recognition Factor (NPLOC4) gene is located on chr17 :79523912-79604138 at 17q25.3.
Gene Name: NPL4 Homolog, Ubiquitin Recognition Factor
Chromosome: CHR17: 79523912 -79604138
Locus: 17q25.3
Gene Diseases
The NPLOC4 P4HB Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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