NPHP3-LSAMP Fusion FISH Probe
The NPHP3-LSAMP Fusion FISH Probe is used to confirm a fusion of the NPHP3 and LSAMP genes. The fusion of the NPHP3 and LSAMP genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NPHP3-LSAMP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-RERE | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-REOR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-REGO | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-REGR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-REAQ | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-ORRE | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-OROR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-ORGO | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-ORAQ | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GORE | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GOOR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GOGO | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GOGR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GOAQ | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GRRE | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GROR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GRGO | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GRGR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-GRAQ | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-AQRE | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-AQOR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-AQGO | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-AQGR | 20 (40 μL) | 200 μL |
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| NPHP3-LSAMP-20-AQAQ | 20 (40 μL) | 200 μL |
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LSAMP Gene Summary
This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Limbic System-associated Membrane Protein
Chromosome: CHR3: 115521209 -116164385
Locus: 3q13.31
NPHP3 Gene Summary
This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. [provided by RefSeq, Feb 2011]
Gene Name: Nephrocystin 3
Chromosome: CHR3: 132399452 -132441303
Locus: 3q22.1
Gene Diseases
The NPHP3 LSAMP Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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