NPC1-OSBPL1A Fusion FISH Probe
The NPC1-OSBPL1A Fusion FISH Probe is used to confirm a fusion of the NPC1 and OSBPL1A genes. The fusion of the NPC1 and OSBPL1A genes has been associated with Uterine Corpus Endometrial Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NPC1-OSBPL1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-RERE | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-REOR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-REGO | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-REGR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-REAQ | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-ORRE | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-OROR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-ORGO | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GORE | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GOOR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GOGO | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GOGR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GRRE | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GROR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GRGO | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GRGR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-AQRE | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-AQOR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-AQGO | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-AQGR | 20 (40 μL) | 200 μL |
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| NPC1-OSBPL1A-20-AQAQ | 20 (40 μL) | 200 μL |
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NPC1 Gene Summary
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
Gene Name: NPC Intracellular Cholesterol Transporter 1
Chromosome: CHR18: 21111462 -21166581
Locus: 18q11.2
OSBPL1A Gene Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Oxysterol Binding Protein Like 1A
Chromosome: CHR18: 21742010 -21977833
Locus: 18q11.2
Gene Diseases
The NPC1 OSBPL1A Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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