NOTCH3-UBTF Fusion FISH Probe
The NOTCH3-UBTF Fusion FISH Probe is used to confirm a fusion of the NOTCH3 and UBTF genes. The fusion of the NOTCH3 and UBTF genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH3-UBTF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH3-UBTF-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH3 Gene Summary
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Gene Name: Notch 3
Chromosome: CHR19: 15270443 -15311792
Locus: 19p13.12
UBTF Gene Summary
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]
Gene Name: Upstream Binding Transcription Factor, RNA Polymerase I
Chromosome: CHR17: 42282400 -42298994
Locus: 17q21.31
Gene Diseases
The NOTCH3 UBTF Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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