NOTCH3-C3 Fusion FISH Probe
The NOTCH3-C3 Fusion FISH Probe is used to confirm a fusion of the NOTCH3 and C3 genes. The fusion of the NOTCH3 and C3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH3-C3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH3-C3-20-AQAQ | 20 (40 μL) | 200 μL |
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C3 Gene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Complement C3
Chromosome: CHR19: 6677845 -6720662
Locus: 19p13.3
NOTCH3 Gene Summary
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Gene Name: Notch 3
Chromosome: CHR19: 15270443 -15311792
Locus: 19p13.12
Gene Diseases
The NOTCH3 C3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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