NOTCH3-BRD4 Fusion FISH Probe
The NOTCH3-BRD4 Fusion FISH Probe is used to confirm a fusion of the NOTCH3 and BRD4 genes. The fusion of the NOTCH3 and BRD4 genes has been associated with Uterine Corpus Endometrial Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH3-BRD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH3-BRD4-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH3 Gene Summary
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Gene Name: Notch 3
Chromosome: CHR19: 15270443 -15311792
Locus: 19p13.12
BRD4 Gene Summary
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Bromodomain Containing 4
Chromosome: CHR19: 15348300 -15391262
Locus: 19p13.12
Gene Diseases
The NOTCH3 BRD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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