NOTCH2-SPAG17 Fusion FISH Probe
The NOTCH2-SPAG17 Fusion FISH Probe is used to confirm a fusion of the NOTCH2 and SPAG17 genes. The fusion of the NOTCH2 and SPAG17 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH2-SPAG17-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH2-SPAG17-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH2 Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Notch 2
Chromosome: CHR1: 120454175 -120612317
Locus: 1p12
SPAG17 Gene Summary
This gene encodes a central pair protein present in the axonemes of cells with a "9 + 2" organization of microtubules. The encoded protein is required for the proper function of the axoneme. Mutations in the orthologous gene in mice lead to primary ciliary dyskinesia characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound respiratory distress, hydrocephalus, and neonatal lethality within twelve hours of birth due to impaired airway mucociliary clearance. Single-nucleotide polymorphisms in this gene are associated with human height and targeted mutations lead to skeletal malformations affecting the limbs in mice, suggesting a role for this gene in skeletal development. [provided by RefSeq, Feb 2017]
Gene Name: Sperm Associated Antigen 17
Chromosome: CHR1: 118496287 -118727848
Locus: 1p12
Gene Diseases
The NOTCH2 SPAG17 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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