NOTCH2-MNDA Fusion FISH Probe
The NOTCH2-MNDA Fusion FISH Probe is used to confirm a fusion of the NOTCH2 and MNDA genes. The fusion of the NOTCH2 and MNDA genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH2-MNDA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH2-MNDA-20-AQAQ | 20 (40 μL) | 200 μL |
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MNDA Gene Summary
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
Gene Name: Myeloid Cell Nuclear Differentiation Antigen
Chromosome: CHR1: 158801167 -158819270
Locus: 1q23.1
NOTCH2 Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Notch 2
Chromosome: CHR1: 120454175 -120612317
Locus: 1p12
Gene Diseases
The NOTCH2 MNDA Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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