NOTCH2-CWH43 Fusion FISH Probe
The NOTCH2-CWH43 Fusion FISH Probe is used to confirm a fusion of the NOTCH2 and CWH43 genes. The fusion of the NOTCH2 and CWH43 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH2-CWH43-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH2-CWH43-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH2 Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Notch 2
Chromosome: CHR1: 120454175 -120612317
Locus: 1p12
CWH43 Gene Summary
The Cell Wall Biogenesis 43 C-terminal Homolog (CWH43) gene is located on chr4 :48988264-49064095 at 4p11.
Gene Name: Cell Wall Biogenesis 43 C-terminal Homolog
Chromosome: CHR4: 48988264 -49064095
Locus: 4p11
Gene Diseases
The NOTCH2 CWH43 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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