SEARCH OUR PRODUCT CATALOG

NOTCH1-MAPK1 Fusion FISH Probe

The NOTCH1-MAPK1 Fusion FISH Probe is used to confirm a fusion of the NOTCH1 and MAPK1 genes. The fusion of the NOTCH1 and MAPK1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NOTCH1-MAPK1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-RERE 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-REOR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-REGO 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-REGR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-REAQ 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-ORRE 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-OROR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-ORGO 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-ORAQ 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GORE 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GOOR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GOGO 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GOGR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GOAQ 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GRRE 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GROR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GRGO 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GRGR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-GRAQ 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-AQRE 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-AQOR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-AQGO 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-AQGR 20 (40 μL) 200 μL
NOTCH1-MAPK1-20-AQAQ 20 (40 μL) 200 μL

NOTCH1 Gene Summary

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]

Gene Name: Notch 1

Chromosome: CHR9: 139388895 -139440238

Locus: 9q34.3

MAPK1 Gene Summary

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

Gene Name: Mitogen-activated Protein Kinase 1

Chromosome: CHR22: 22113946 -22221970

Locus: 22q11.22

Gene Diseases

The NOTCH1 MAPK1 Fusion has been associated with the following diseases:

Disease Name
Head And Neck Squamous Cell Carcinoma 

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.