NOTCH1-MAPK1 Fusion FISH Probe
The NOTCH1-MAPK1 Fusion FISH Probe is used to confirm a fusion of the NOTCH1 and MAPK1 genes. The fusion of the NOTCH1 and MAPK1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH1-MAPK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH1-MAPK1-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH1 Gene Summary
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Gene Name: Notch 1
Chromosome: CHR9: 139388895 -139440238
Locus: 9q34.3
MAPK1 Gene Summary
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Mitogen-activated Protein Kinase 1
Chromosome: CHR22: 22113946 -22221970
Locus: 22q11.22
Gene Diseases
The NOTCH1 MAPK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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