NOTCH1-LCN10 Fusion FISH Probe
The NOTCH1-LCN10 Fusion FISH Probe is used to confirm a fusion of the NOTCH1 and LCN10 genes. The fusion of the NOTCH1 and LCN10 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH1-LCN10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH1-LCN10-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH1 Gene Summary
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Gene Name: Notch 1
Chromosome: CHR9: 139388895 -139440238
Locus: 9q34.3
LCN10 Gene Summary
Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Gene Name: Lipocalin 10
Chromosome: CHR9: 139632618 -139637411
Locus: 9q34.3
Gene Diseases
The NOTCH1 LCN10 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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