NOTCH1-HNF1B Fusion FISH Probe
The NOTCH1-HNF1B Fusion FISH Probe is used to confirm a fusion of the NOTCH1 and HNF1B genes. The fusion of the NOTCH1 and HNF1B genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH1-HNF1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH1-HNF1B-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH1 Gene Summary
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Gene Name: Notch 1
Chromosome: CHR9: 139388895 -139440238
Locus: 9q34.3
HNF1B Gene Summary
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Name: HNF1 Homeobox B
Chromosome: CHR17: 36046433 -36105096
Locus: 17q12
Gene Diseases
The NOTCH1 HNF1B Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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