NOS1AP-PBX1 Fusion FISH Probe
The NOS1AP-PBX1 Fusion FISH Probe is used to confirm a fusion of the NOS1AP and PBX1 genes. The fusion of the NOS1AP and PBX1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOS1AP-PBX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-RERE | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-REOR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-REGO | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-REGR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-REAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-ORRE | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-OROR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-ORGO | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GORE | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GOOR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GOGO | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GOGR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GRRE | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GROR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GRGO | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GRGR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-AQRE | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-AQOR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-AQGO | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-AQGR | 20 (40 μL) | 200 μL |
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| NOS1AP-PBX1-20-AQAQ | 20 (40 μL) | 200 μL |
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PBX1 Gene Summary
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: PBX Homeobox 1
Chromosome: CHR1: 164528596 -164821060
Locus: 1q23.3
NOS1AP Gene Summary
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Gene Name: Nitric Oxide Synthase 1 Adaptor Protein
Chromosome: CHR1: 162039580 -162339813
Locus: 1q23.3
Gene Diseases
The NOS1AP PBX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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