NOS1AP-F5 Fusion FISH Probe
The NOS1AP-F5 Fusion FISH Probe is used to confirm a fusion of the NOS1AP and F5 genes. The fusion of the NOS1AP and F5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOS1AP-F5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-RERE | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-REOR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-REGO | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-REGR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-REAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-ORRE | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-OROR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-ORGO | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GORE | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GOOR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GOGO | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GOGR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GRRE | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GROR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GRGO | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GRGR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-AQRE | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-AQOR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-AQGO | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-AQGR | 20 (40 μL) | 200 μL |
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| NOS1AP-F5-20-AQAQ | 20 (40 μL) | 200 μL |
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F5 Gene Summary
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
Gene Name: Coagulation Factor V
Chromosome: CHR1: 169481191 -169555769
Locus: 1q24.2
NOS1AP Gene Summary
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Gene Name: Nitric Oxide Synthase 1 Adaptor Protein
Chromosome: CHR1: 162039580 -162339813
Locus: 1q23.3
Gene Diseases
The NOS1AP F5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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