NOS1AP-ATF6 Fusion FISH Probe
The NOS1AP-ATF6 Fusion FISH Probe is used to confirm a fusion of the NOS1AP and ATF6 genes. The fusion of the NOS1AP and ATF6 genes has been associated with Uterine Corpus Endometrial Carcinoma, Uterine Corpus Endometrial Carcinoma, and Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOS1AP-ATF6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-RERE | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-REOR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-REGO | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-REGR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-REAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-ORRE | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-OROR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-ORGO | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GORE | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GOOR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GOGO | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GOGR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GRRE | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GROR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GRGO | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GRGR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-AQRE | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-AQOR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-AQGO | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-AQGR | 20 (40 μL) | 200 μL |
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| NOS1AP-ATF6-20-AQAQ | 20 (40 μL) | 200 μL |
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NOS1AP Gene Summary
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Gene Name: Nitric Oxide Synthase 1 Adaptor Protein
Chromosome: CHR1: 162039580 -162339813
Locus: 1q23.3
ATF6 Gene Summary
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Gene Name: Activating Transcription Factor 6
Chromosome: CHR1: 161736033 -161933860
Locus: 1q23.3
Gene Diseases
The NOS1AP ATF6 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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