NOS1-UBC Fusion FISH Probe
The NOS1-UBC Fusion FISH Probe is used to confirm a fusion of the NOS1 and UBC genes. The fusion of the NOS1 and UBC genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOS1-UBC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-RERE | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-REOR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-REGO | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-REGR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-REAQ | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-ORRE | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-OROR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-ORGO | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GORE | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GOOR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GOGO | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GOGR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GRRE | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GROR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GRGO | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GRGR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-AQRE | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-AQOR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-AQGO | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-AQGR | 20 (40 μL) | 200 μL |
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| NOS1-UBC-20-AQAQ | 20 (40 μL) | 200 μL |
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NOS1 Gene Summary
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Nitric Oxide Synthase 1
Chromosome: CHR12: 117645946 -117799607
Locus: 12q24.22
UBC Gene Summary
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]
Gene Name: Ubiquitin C
Chromosome: CHR12: 125396191 -125399587
Locus: 12q24.31
Gene Diseases
The NOS1 UBC Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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