NNT-PRLR Fusion FISH Probe
The NNT-PRLR Fusion FISH Probe is used to confirm a fusion of the NNT and PRLR genes. The fusion of the NNT and PRLR genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NNT-PRLR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-RERE | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-REOR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-REGO | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-REGR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-REAQ | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-ORRE | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-OROR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-ORGO | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-ORAQ | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GORE | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GOOR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GOGO | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GOGR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GOAQ | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GRRE | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GROR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GRGO | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GRGR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-GRAQ | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-AQRE | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-AQOR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-AQGO | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-AQGR | 20 (40 μL) | 200 μL |
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| NNT-PRLR-20-AQAQ | 20 (40 μL) | 200 μL |
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PRLR Gene Summary
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Gene Name: Prolactin Receptor
Chromosome: CHR5: 35055801 -35230823
Locus: 5p13.2
NNT Gene Summary
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016]
Gene Name: Nicotinamide Nucleotide Transhydrogenase
Chromosome: CHR5: 43602790 -43705668
Locus: 5p12
Gene Diseases
The NNT PRLR Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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