NLRC5-FTO Fusion FISH Probe
The NLRC5-FTO Fusion FISH Probe is used to confirm a fusion of the NLRC5 and FTO genes. The fusion of the NLRC5 and FTO genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NLRC5-FTO-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-RERE | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-REOR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-REGO | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-REGR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-REAQ | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-ORRE | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-OROR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-ORGO | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-ORAQ | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GORE | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GOOR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GOGO | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GOGR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GOAQ | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GRRE | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GROR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GRGO | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GRGR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-GRAQ | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-AQRE | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-AQOR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-AQGO | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-AQGR | 20 (40 μL) | 200 μL |
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| NLRC5-FTO-20-AQAQ | 20 (40 μL) | 200 μL |
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FTO Gene Summary
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Gene Name: FTO, Alpha-ketoglutarate Dependent Dioxygenase
Chromosome: CHR16: 53737874 -54148379
Locus: 16q12.2
NLRC5 Gene Summary
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Gene Name: NLR Family CARD Domain Containing 5
Chromosome: CHR16: 57023409 -57117436
Locus: 16q13
Gene Diseases
The NLRC5 FTO Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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