NKX3-1-SEC63 Fusion FISH Probe
The NKX3-1-SEC63 Fusion FISH Probe is used to confirm a fusion of the NKX3-1 and SEC63 genes. The fusion of the NKX3-1 and SEC63 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NKX3-1-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| NKX3-1-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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NKX3-1 Gene Summary
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
Gene Name: NK3 Homeobox 1
Chromosome: CHR8: 23536205 -23540450
Locus: 8p21.2
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The NKX3-1 SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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