NKX2-1-SLC25A21 Fusion FISH Probe
The NKX2-1-SLC25A21 Fusion FISH Probe is used to confirm a fusion of the NKX2-1 and SLC25A21 genes. The fusion of the NKX2-1 and SLC25A21 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NKX2-1-SLC25A21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-RERE | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-REOR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-REGO | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-REGR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-REAQ | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-ORRE | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-OROR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-ORGO | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-ORAQ | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GORE | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GOOR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GOGO | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GOGR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GOAQ | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GRRE | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GROR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GRGO | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GRGR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-GRAQ | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-AQRE | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-AQOR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-AQGO | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-AQGR | 20 (40 μL) | 200 μL |
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| NKX2-1-SLC25A21-20-AQAQ | 20 (40 μL) | 200 μL |
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NKX2-1 Gene Summary
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]
Gene Name: NK2 Homeobox 1
Chromosome: CHR14: 36985603 -36989430
Locus: 14q13.3
SLC25A21 Gene Summary
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
Gene Name: Solute Carrier Family 25 Member 21
Chromosome: CHR14: 37147125 -37641865
Locus: 14q13.3
Gene Diseases
The NKX2-1 SLC25A21 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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