NKRF-UBE2A Fusion FISH Probe
The NKRF-UBE2A Fusion FISH Probe is used to confirm a fusion of the NKRF and UBE2A genes. The fusion of the NKRF and UBE2A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NKRF-UBE2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-RERE | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-REOR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-REGO | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-REGR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-REAQ | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-ORRE | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-OROR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-ORGO | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GORE | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GOOR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GOGO | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GOGR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GRRE | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GROR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GRGO | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GRGR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-AQRE | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-AQOR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-AQGO | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-AQGR | 20 (40 μL) | 200 μL |
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| NKRF-UBE2A-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE2A Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: Ubiquitin Conjugating Enzyme E2 A
Chromosome: CHRX: 118708498 -118718379
Locus: Xq24
NKRF Gene Summary
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Name: NFKB Repressing Factor
Chromosome: CHRX: 118722299 -118739846
Locus: Xq24
Gene Diseases
The NKRF UBE2A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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